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Watch Intently (one)pentobarbital will lessen the extent or impact of glecaprevir/pibrentasvir by impacting hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will increase toxicity of ifosfamide by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check. CYP3A4 inducers might enhance the metabolism of ifosfamide to its ac